Detection of minimal residual disease in childhood acute lymphoblastic leukemia after termination of therapy.
Pediatr Hematol Oncol
; 13(3): 257-63, 1996.
Article
in En
| MEDLINE
| ID: mdl-8735342
ABSTRACT
Using IgH and TCR gamma gene rearrangements as gene markers, we detected minimal residual disease (MRD) by means of the polymerase chain reaction (PCR) and restriction analysis. Of 18 children with acute lymphoblastic leukemia (ALL), MRDs were detected in 9 patients after termination of therapy. All 18 patients had been followed for 1.5 to 102 months after detection. Three of the nine MRD-positive patients relapsed within 3 to 6 months; none of the nine MRD-negative patients relapsed. We suggest that MRD negativity at the end of therapy might be an important factor for long-term disease-free survival, because the negative cases had a very low risk of relapse. Because the outcome for MRD-positive cases is more difficult to evaluate, patients with MRD after termination of therapy should be monitored.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genes, Immunoglobulin
/
Polymerase Chain Reaction
/
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Journal:
Pediatr Hematol Oncol
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Year:
1996
Document type:
Article
Affiliation country:
China