Nuclear morphometry in squamous cell carcinoma (SCC) of the tongue.
Eur J Cancer B Oral Oncol
; 32B(2): 91-6, 1996 Mar.
Article
in En
| MEDLINE
| ID: mdl-8736170
ABSTRACT
In the histological grading of oral squamous cell carcinoma (OSCC) nuclear features are very important. Nevertheless evaluation is usually performed in a subjective and not highly reproducible way. The aim of this work was to investigate the relationship between nuclear shape and survival in 30 cases of carcinoma of the tongue. All the patients were divided into two groups short-term survival and long-term survival. Twenty nuclei for each tumour were submitted to a morphometrical study by the shape analytical morphometry (SAM) software system. It was thus possible to evaluate not only nuclear dimensions but also nuclear contour irregularities and nuclear shape asymmetries. Multivariate discriminant analysis (MDA) of the quantitative parameters obtained by the morphometrical study distinguished the patients of the two groups with only a 10% error; moreover successful cluster analysis was performed by using Fourier parameters. Both these sets of results were achieved mainly owing to the parameters for contour irregularities.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tongue Neoplasms
/
Carcinoma, Squamous Cell
/
Cell Nucleus
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Eur J Cancer B Oral Oncol
Journal subject:
NEOPLASIAS
/
ODONTOLOGIA
Year:
1996
Document type:
Article
Affiliation country:
Italy