Dextran modification of a Fab'--beta-lactamase conjugate modulated by variable pretreatment of Fab' with amine-blocking reagents.

Mikolajczyk, S D; Meyer, D L; Fagnani, R; Hagan, M S; Law, K L; Starling, J J

Mikolajczyk, S D; Meyer, D L; Fagnani, R; Hagan, M S; Law, K L; Starling, J J.

Affiliation

Mikolajczyk SD; Hybritech Inc., San Diego, California 92196-9006, USA.

Bioconjug Chem ; 7(1): 150-8, 1996.

Article in En | MEDLINE | ID: mdl-8742004

Subject(s)

Dextrans; Immunoglobulin Fab Fragments; beta-Lactamases; Animals; Antibodies; Antigens, Neoplasm/immunology; Carcinoembryonic Antigen/immunology; Enzyme-Linked Immunosorbent Assay; Glycoproteins/immunology; Half-Life; Humans; Imides; Indicators and Reagents; Iodine Radioisotopes; Mice; Mice, Nude; Neoplasms/metabolism; Radioimmunoassay; Structure-Activity Relationship; Tissue Distribution; Transplantation, Heterologous; Tumor Cells, Cultured; beta-Lactamases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Immunoglobulin Fab Fragments / Dextrans Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 1996 Document type: Article Affiliation country: United States Country of publication: United States

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