Intraoperative fall in plasma levels of intact parathyroid hormone in patients undergoing parathyroid adenomectomy.
Int J Biol Markers
; 10(4): 206-10, 1995.
Article
in En
| MEDLINE
| ID: mdl-8750646
ABSTRACT
Intraoperative measurement of intact parathyroid hormone (PTH) can be used to evaluate the success of parathyroid surgery in primary hyperparathyroidism associated with parathyroid adenoma. To evaluate this approach we used a modified immunoradiometric assay (IRMA) to study the kinetic patterns of circulating PTH disappearance in 13 patients undergoing adenomectomy for single adenoma. The rapid and the standard assay for PTH measurement in plasma were used and compared. The two methods showed a highly significant correlation (r = 0.995; p < 0.0001). We reported a decrease in PTH to 18.2 +/- 2.30 (mean +/- SEM) from baseline values at 15 minutes after successful parathyroid adenomectomy in the 13 patients. The biphasic pattern of serum PTH clearance was calculated in 8 of the studied patients with a fast phase showing a half-life (T1/2) of 3.99 (SEM 0.464) minutes and a slow phase with a T1/2 of 91.0 (SEM 33.6) minutes. Half the amount of the basal values was reached between 4 and 9 minutes. Our study concludes that the modified IRMA for intraoperative measurement is feasible, reliable and sufficiently precise for low hormone values. Since it may yield information on the half-life of PTH in the circulation, it may play a role in the surgical guidance for total exeresis of hyperfunctioning tissue.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parathyroid Hormone
/
Parathyroid Neoplasms
/
Adenoma
/
Parathyroidectomy
/
Hyperparathyroidism
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Biol Markers
Journal subject:
BIOQUIMICA
/
NEOPLASIAS
Year:
1995
Document type:
Article
Affiliation country:
Italy
Country of publication:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA