[G-CSF in patients with lupus-associated neutropenia and infections]. / G-CSF bei Patienten mit Lupus-assoziierter Neutropenie und Infektionen.
Z Rheumatol
; 55(3): 174-9, 1996.
Article
in De
| MEDLINE
| ID: mdl-8768147
ABSTRACT
Nine patients with SLE-associated neutropenia and infections received 48 Mio U G-CSF per day s.c. for 2-17 days as an adjunct to antibiotic treatment. Granulopoiesis was normal or hyperplastic in all cases. The mean granulocyte count increased within 2 days from 1.4 per nl to 11.4 per nl. Side-effects were exacerbating CNS symptoms in two patients and a case of leukocytoclastic vasculitis. G-CSF induced constantly a rapid and distinct increase of neutrophil granulocytes in lupus-associated neutropenia patients with normo- or hyperplastic granulopoiesis.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Opportunistic Infections
/
Granulocyte Colony-Stimulating Factor
/
Lupus Erythematosus, Systemic
/
Neutropenia
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
De
Journal:
Z Rheumatol
Year:
1996
Document type:
Article