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Post-meal coagulation activation in diabetes mellitus: the effect of acarbose.
Ceriello, A; Taboga, C; Tonutti, L; Giacomello, R; Stel, L; Motz, E; Pirisi, M.
Affiliation
  • Ceriello A; Department of Medicine and Pathology, University of Udine, Italy.
Diabetologia ; 39(4): 469-73, 1996 Apr.
Article in En | MEDLINE | ID: mdl-8777997
It has been previously demonstrated that hyperglycaemia activates haemostasis; diabetes mellitus is considered a thrombosis-prone state. Acarbose, by inhibiting dietary carbohydrate absorption, reduces post-meal hyperglycaemia. In this study we evaluated the effect of post-meal hyperglycaemia on two markers of coagulation activation: prothrombin fragments 1 + 2 and D-dimer. Seventeen non-insulin-dependent diabetic patients maintained on diet therapy alone were randomly assigned to receive- with a cross-over study design-acarbose (100 mg orally) or placebo before a standard meal. Blood samples for measurement of plasma glucose, insulin, prothrombin fragments 1 + 2 and D-dimer were drawn at 0, 60, 120 and 240 min. After both placebo and acarbose, hyperglycaemia and hyperinsulinaemia which followed a standard meal were accompanied by a significant increase of plasma concentration of prothrombin fragments 1 + 2 and D-dimer in comparison to their baseline values. Acarbose administration significantly reduced the rise of glucose, insulin, prothrombin fragments 1 + 2 and D-dimer from 0 to 240 min in comparison to placebo. We conclude that post-meal hyperglycaemia, at the level reached by many diabetic patients on diet therapy alone, induces a coagulation activation. Acarbose, by decreasing post-meal hyperglycaemia, may be useful in reducing meal-induced activation of haemostasis in diabetic patients.
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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Protein Precursors / Trisaccharides / Blood Coagulation / Prothrombin / Diabetes Mellitus, Type 2 / Eating / Hyperglycemia / Hypoglycemic Agents Type of study: Clinical_trials Limits: Humans / Male / Middle aged Language: En Journal: Diabetologia Year: 1996 Document type: Article Affiliation country: Italy Country of publication: Germany
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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Protein Precursors / Trisaccharides / Blood Coagulation / Prothrombin / Diabetes Mellitus, Type 2 / Eating / Hyperglycemia / Hypoglycemic Agents Type of study: Clinical_trials Limits: Humans / Male / Middle aged Language: En Journal: Diabetologia Year: 1996 Document type: Article Affiliation country: Italy Country of publication: Germany