Canine visceral leishmaniasis: successful chemotherapy induces macrophage antileishmanial activity via the L-arginine nitric oxide pathway.
Antimicrob Agents Chemother
; 40(1): 253-6, 1996 Jan.
Article
in En
| MEDLINE
| ID: mdl-8787918
ABSTRACT
Following successful chemotherapy in canine visceral leishmaniasis, monocyte-derived macrophages can induce antileishmanial activity via a gamma interferon-dependent mechanism in the presence of autologous lymphocytes. The killing of leishmania correlated with the induction of the NO synthase pathway, because it correlated with the generation of nitrogen derivative production and was abrogated in the presence of NG-monomethyl-L-arginine, a competitive inhibitor of the NO synthase pathway. The level of L-citrulline in serum, which was produced after activation of the NO synthase pathway, was markedly enhanced in dogs receiving successful chemotherapy. Taken together, these data indicate that following successful chemotherapy of visceral leishmaniasis, leishmania parasites are killed by macrophages activated by gamma interferon-producing lymphocytes via an NO-dependent mechanism.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leishmania infantum
/
Dog Diseases
/
Leishmaniasis, Visceral
/
Macrophages
/
Nitric Oxide
Limits:
Animals
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
1996
Document type:
Article
Affiliation country:
France