Transforming growth factor-beta 1 promotes re-elongation of injured axons of cultured rat hippocampal neurons.
Brain Res
; 723(1-2): 206-9, 1996 Jun 03.
Article
in En
| MEDLINE
| ID: mdl-8813400
ABSTRACT
Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following axotomy was investigated. The axonal growth was stopped by laser irradiation, but addition of TGF-beta 1 remarkably promoted the axonal re-elongation from the injured site. The effect of TGF-beta 1 was concentration dependent and seen maximally at a concentration of 1 ng/ml. These results suggest that TGF-beta 1 has a capability of promoting axonal regeneration of brain neurons after lesioning.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Axons
/
Transforming Growth Factor beta
/
Hippocampus
Limits:
Animals
Language:
En
Journal:
Brain Res
Year:
1996
Document type:
Article
Affiliation country:
Japan