Cyclic nucleotide-gated ion channels: an extended family with diverse functions.
Annu Rev Physiol
; 58: 395-426, 1996.
Article
in En
| MEDLINE
| ID: mdl-8815801
ABSTRACT
An ion channel directly activated by cGMP was first discovered about ten years ago. Since then, a number of ion channels with the same property (cyclic nucleotide-activated channels) have been reported that are involved in a variety of cell functions. In addition, other channels have been found that are not primarily controlled by cyclic nucleotides but are modulated by them (cyclic nucleotide-modulated channels). These channels likewise have diverse functions and tissue distributions. Both channel classes are reviewed here. Coverage includes the cyclic-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating and modulation, and physiological functions of the channels.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ion Channel Gating
/
Cyclic AMP
/
Cyclic GMP
/
Ion Channels
Limits:
Animals
/
Humans
Language:
En
Journal:
Annu Rev Physiol
Year:
1996
Document type:
Article
Affiliation country:
United States
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA