Prolonged, complete remission after 2-chlorodeoxyadenosine therapy in a patient with refractory essential mixed cryoglobulinemia.
Mayo Clin Proc
; 71(10): 966-8, 1996 Oct.
Article
in En
| MEDLINE
| ID: mdl-8820771
ABSTRACT
Essential mixed cryoglobulinemia is a systemic disorder in which cutaneous vasculitis and frequently glomerulonephritis are associated with cryoprecipitable serum immune complexes. Typically, the treatment regimen consists of plasmapheresis, high-dose corticosteroids, and cytotoxic chemotherapy, as well as interferon alfa for hepatitis C virus-related cryoglobulinemia. Herein we describe a man with progressive, symptomatic cryoglobulinemia and multisystem organ dysfunction in whom corticosteroid and alkylating therapy failed; however, he had a complete and long-lasting remission after administration of 2-chlorodeoxyadenosine (cladribine).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cladribine
/
Cryoglobulinemia
/
Immunosuppressive Agents
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Mayo Clin Proc
Year:
1996
Document type:
Article
Affiliation country:
United States