Biochemical and molecular studies of human methenyltetrahydrofolate synthetase.
Stem Cells
; 14(1): 33-40, 1996 Jan.
Article
in En
| MEDLINE
| ID: mdl-8820949
ABSTRACT
5-FormylH4folate is administered clinically under the name Leucovorin in association with the antineoplastic agent 5-fluorouracil (5-FU) to enhance the cytotoxic effects of 5-FU. The combination has been shown to be superior to 5-FU alone in the treatment of patients with metastatic colorectal carcinoma. Methenyltetrahydrofolate synthetase (MTHFS) catalyzes the transformation of 5-formyl-tetrahydrofolate to methenylH4folate, which is the obligatory initial metabolic step prior to the intracellular conversion of 5-formylH4folate to other reduced folates and the increase in intracellular folate pools required for 5-FU potentiation. In the following paper, we will summarize results of biochemical and molecular studies of human MTHFS.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carbon-Nitrogen Ligases
/
Ligases
Limits:
Animals
/
Humans
Language:
En
Journal:
Stem Cells
Year:
1996
Document type:
Article
Affiliation country:
Canada