Metabotropic glutamate receptor antagonist, (R,S)-alpha-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus.
Neurosci Lett
; 201(1): 73-6, 1995 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-8830317
ABSTRACT
The necessity of metabotropic glutamate receptors (mGluRs) in the induction of long-term potentiation (LTP) has recently been questioned. We examined the effect of (R,S)-alpha-methyl-4-caboxyphenylglycine (MCPG), a selective mGluR antagonist, on two independent forms of LTP. One form induced by a 25 Hz/1 s tetanus is solely N-methyl-D-aspartate (NMDA) receptor-dependent. The other form induced by four 200 Hz/0.5 s bursts in the presence of APV is NMDA receptor-independent. In both paradigms the presence of MCPG prevented the induction of LTP by afferent activation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzoates
/
Receptors, Metabotropic Glutamate
/
Long-Term Potentiation
/
Excitatory Amino Acid Antagonists
/
Glycine
/
Hippocampus
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
1995
Document type:
Article
Affiliation country:
United States