Exogenous heparin induces an increase in glycosaminoglycans of the chick embryo chorioallantoic membrane: its possible role in the regulation of angiogenic processes.
Int J Microcirc Clin Exp
; 15(4): 181-5, 1995.
Article
in En
| MEDLINE
| ID: mdl-8847178
ABSTRACT
In this study heparin (HE) was injected into the allantoic sac of chick embryo eggs at 5, 9, 14 days of incubation. 48 h after injection glycosaminoglycan (GAG) concentration was measured in the chorioallantoic membrane (CAM) in order to verify if HE-related CAM angiogenic activity previously demonstrated [Ribatti et al Acta Anat 1987; 130257-263] might be correlated with changes in GAG concentration. The results showed that HE inoculation induced an increase of 3H-glucosamine incorporation into total GAGs in comparison to control CAMs. Furthermore, HE altered the balance between the GAG classes, and in particular it produced a significant increase in the accumulation of hyaluronic acid and heparan sulfate between 7 and 11 days of incubation in comparison to control CAMs.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heparin
/
Chorion
/
Neovascularization, Physiologic
/
Allantois
/
Glycosaminoglycans
Limits:
Animals
Language:
En
Journal:
Int J Microcirc Clin Exp
Year:
1995
Document type:
Article
Affiliation country:
Italy