Hydroxyethyl cyclosporin A induces and decreases P4503A and P-glycoprotein levels in rat liver.

Vickers, A E; Alegret, M; Meyer, E; Smiley, S; Guertler, J

Vickers, A E; Alegret, M; Meyer, E; Smiley, S; Guertler, J.

Affiliation

Vickers AE; Drug Safety, Sandoz Pharma Ltd, Basle, Switzerland.

Xenobiotica ; 26(1): 27-39, 1996 Jan.

Article in En | MEDLINE | ID: mdl-8851819

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Cyclosporins/pharmacology; Cytochrome P-450 Enzyme System/metabolism; Immunosuppressive Agents/pharmacology; Mixed Function Oxygenases/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1/biosynthesis; Animals; Arachidonic Acid/metabolism; Biotransformation; Cyclosporins/pharmacokinetics; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System/biosynthesis; Enzyme Induction/drug effects; Immunoblotting; Immunosuppressive Agents/pharmacokinetics; In Vitro Techniques; Kidney/drug effects; Kidney/enzymology; Kidney/metabolism; Lauric Acids/metabolism; Liver/drug effects; Liver/enzymology; Liver/metabolism; Male; Mixed Function Oxygenases/biosynthesis; Oxidation-Reduction; Rats; Rats, Wistar; Subcellular Fractions/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: ATP Binding Cassette Transporter, Subfamily B, Member 1 / Cyclosporins / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases / Immunosuppressive Agents Limits: Animals Language: En Journal: Xenobiotica Year: 1996 Document type: Article Affiliation country: Switzerland Country of publication: United kingdom

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