Membrane Glycoproteins/genetics; Podophyllin/analogs & derivatives; Proto-Oncogene Proteins/metabolism; T-Lymphocytes, Cytotoxic/metabolism; Transcription Factors/metabolism; Animals; Base Sequence; Binding Sites/genetics; Cell Line; Chloramphenicol O-Acetyltransferase/genetics; DNA/genetics; DNA/metabolism; Enhancer Elements, Genetic; Female; Gene Expression Regulation; Genes, Reporter; HeLa Cells; Humans; In Vitro Techniques; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutagenesis, Site-Directed; Perforin; Podophyllin/metabolism; Podophyllotoxin/analogs & derivatives; Point Mutation; Pore Forming Cytotoxic Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins c-ets