CRH-R1 mRNA expression in two strains of inbred mice and its regulation after repeated restraint stress.

Giardino, L; Puglisi-Allegra, S; Ceccatelli, S

Giardino, L; Puglisi-Allegra, S; Ceccatelli, S.

Affiliation

Giardino L; Institute of Otolaryngology II, University of Milan, Modena, Italy.

Brain Res Mol Brain Res ; 40(2): 310-4, 1996 Sep 01.

Article in En | MEDLINE | ID: mdl-8872315

ABSTRACT

Using in-situ hybridization histochemistry we investigated the distribution of CRH receptor 1 (CRH-R1) mRNA in the cortex of C57BL/6 (C57) and DBA/2 (DBA) strains and its regulation after repeated restraint stress. We show that DBA mice have a higher concentration of CRH-R1 mRNA than C57 mice. Repeated restraint stress produced an increase in CRH-R1 mRNA expression of C57 mice, whereas it was uneffective in DBA mice.

Subject(s)

Brain/metabolism; Corticotropin-Releasing Hormone/metabolism; Mice, Inbred C57BL/metabolism; Mice, Inbred DBA/metabolism; Stress, Psychological/metabolism; Animals; Male; Mice; RNA, Messenger/metabolism; Restraint, Physical

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Collection: 01-internacional Database: MEDLINE Main subject: Stress, Psychological / Brain / Corticotropin-Releasing Hormone / Mice, Inbred C57BL / Mice, Inbred DBA Limits: Animals Language: En Journal: Brain Res Mol Brain Res Journal subject: BIOLOGIA MOLECULAR / CEREBRO Year: 1996 Document type: Article Affiliation country: Italy Country of publication: Netherlands

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