The control of gene expression in melanocytes and melanomas.
Melanoma Res
; 6(4): 277-84, 1996 Aug.
Article
in En
| MEDLINE
| ID: mdl-8873046
ABSTRACT
Powerful evidence exists that deregulation of cell type-specific gene expression is a major feature of the genesis of several cancers, with many oncogenic proteins known to possess transcription regulation properties. As a consequence of this deregulation, melanomas may ectopically express HLA-DR and also fall to express enzymes required for melanin synthesis, resulting in amelanotic melanoma. Recent work has demonstrated that these phenomena may be accounted for by the expression of a transcription factor called Brn-2, now known to be involved with the development of neural crest-derived tissues. Brn-2 is normally expressed at high levels in melanoblasts and melanomas but only at low levels in normal melanocytes. Brn-2 may act by competing with another transcription factor, ml, necessary for normal melanocyte development.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation, Neoplastic
/
Gene Expression Regulation
/
Melanocytes
/
Melanoma
Limits:
Animals
/
Humans
Language:
En
Journal:
Melanoma Res
Journal subject:
NEOPLASIAS
Year:
1996
Document type:
Article
Affiliation country:
United kingdom