Placental transfer and maternal and fetal hemodynamic effects of ketanserin in the pregnant ewe.
Eur J Obstet Gynecol Reprod Biol
; 68(1-2): 179-84, 1996 Sep.
Article
in En
| MEDLINE
| ID: mdl-8886704
ABSTRACT
OBJECTIVE:
To determine placental transfer of ketanserin and to assess the effect of serotonin-2 receptor blockade by ketanserin on serotonin- and phenylephrine-induced vasoconstriction. STUDYDESIGN:
Five chronically instrumented pregnant ewes at 120 days gestation were injected with 20 mg ketanserin i.v., and fetal and maternal arterial samples were obtained at predetermined intervals to assess placental transfer. Maternal and fetal responses of blood flows and pressures were determined after injected of serotonin (20 micrograms/kg) or phenylephrine (10 micrograms/kg) before and after ketanserin (0.75 mg/kg).RESULTS:
In the ewe, ketanserin is transferred across the placenta and reaches measurable levels in the fetal lamb. Ketanserin blocks the maternal and fetal serotonin-induced rise in arterial pressure, but not the serotonin-induced reduction in uterine blood flow.CONCLUSION:
In the pregnant ewe, the serotonin-induced rise in maternal and fetal blood pressure is effectively antagonized by ketanserin, whereas the serotonin-induced reduction in uterine blood flow is not.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Placenta
/
Serotonin Antagonists
/
Ketanserin
/
Fetus
/
Hemodynamics
/
Maternal-Fetal Exchange
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Eur J Obstet Gynecol Reprod Biol
Year:
1996
Document type:
Article
Affiliation country:
Netherlands
Publication country:
IE
/
IRELAND
/
IRLANDA