Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: application to the synthesis and optimization of corticotropin-releasing factor1 receptor antagonists.

Whitten, J P; Xie, Y F; Erickson, P E; Webb, T R; De Souza, E B; Grigoriadis, D E; McCarthy, J R

Whitten, J P; Xie, Y F; Erickson, P E; Webb, T R; De Souza, E B; Grigoriadis, D E; McCarthy, J R.

Affiliation

Whitten JP; Neurocrine Biosciences, San Diego, California 92121, USA.

J Med Chem ; 39(22): 4354-7, 1996 Oct 25.

Article in En | MEDLINE | ID: mdl-8893828

Subject(s)

Drug Compounding/methods; Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors; Triazines/chemistry; Cell Line; Humans; Robotics/methods; Solutions; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Triazines / Receptors, Corticotropin-Releasing Hormone / Drug Compounding Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1996 Document type: Article Affiliation country: United States Country of publication: United States

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