Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists.

Chen, C; Dagnino, R; De Souza, E B; Grigoriadis, D E; Huang, C Q; Kim, K I; Liu, Z; Moran, T; Webb, T R; Whitten, J P; Xie, Y F; McCarthy, J R

Chen, C; Dagnino, R; De Souza, E B; Grigoriadis, D E; Huang, C Q; Kim, K I; Liu, Z; Moran, T; Webb, T R; Whitten, J P; Xie, Y F; McCarthy, J R.

Affiliation

Chen C; Neurocrine Biosciences, San Diego, California 92121, USA.

J Med Chem ; 39(22): 4358-60, 1996 Oct 25.

Article in En | MEDLINE | ID: mdl-8893829

Subject(s)

Aniline Compounds/chemistry; Drug Compounding/methods; Drug Design; Pyrimidines/chemistry; Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors; Corticotropin-Releasing Hormone/metabolism; Cyclic AMP/metabolism; Humans; Kinetics; Receptors, Corticotropin-Releasing Hormone/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Drug Design / Receptors, Corticotropin-Releasing Hormone / Drug Compounding / Aniline Compounds Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1996 Document type: Article Affiliation country: United States Country of publication: United States

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