Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

Hansen, K; Johnell, M; Siegbahn, A; Rorsman, C; Engström, U; Wernstedt, C; Heldin, C H; Rönnstrand, L

Hansen, K; Johnell, M; Siegbahn, A; Rorsman, C; Engström, U; Wernstedt, C; Heldin, C H; Rönnstrand, L.

Affiliation

Hansen K; Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden.

EMBO J ; 15(19): 5299-313, 1996 Oct 01.

Article in En | MEDLINE | ID: mdl-8895575

Subject(s)

Chemotaxis/physiology; Proto-Oncogene Proteins pp60(c-src)/metabolism; Receptors, Platelet-Derived Growth Factor/metabolism; Actins/metabolism; Amino Acid Sequence; Becaplermin; Cell Division; Cell Line; Chromones/pharmacology; Enzyme Inhibitors/pharmacology; HeLa Cells; Humans; Isoenzymes/metabolism; Kinetics; Molecular Sequence Data; Morpholines/pharmacology; Mutation; Peptides/chemical synthesis; Peptides/metabolism; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation/drug effects; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors; Platelet-Derived Growth Factor/pharmacology; Protein Binding; Protein Kinase C/antagonists & inhibitors; Proto-Oncogene Proteins c-sis; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor/genetics; Recombinant Fusion Proteins/metabolism; Signal Transduction/physiology; Type C Phospholipases/metabolism; Tyrosine/metabolism; src Homology Domains

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemotaxis / Proto-Oncogene Proteins pp60(c-src) / Receptors, Platelet-Derived Growth Factor Language: En Journal: EMBO J Year: 1996 Document type: Article Affiliation country: Sweden

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