Changes in concentrations of methylglyoxal, D-lactate and glyoxalase activities in liver and plasma of rats fed a 3'-methyl-4-dimethylaminoazobenzene-rich diet.
Res Exp Med (Berl)
; 196(4): 251-9, 1996.
Article
in En
| MEDLINE
| ID: mdl-8903102
ABSTRACT
Donryu male albino rats were fed a diet containing 0.064% 3'-methyl-4-dimethylaminoazobenzene (MDAB) for 21 weeks. During the ensuing rat liver carcinogenesis, changes in the concentrations of methylglyoxal, D-lactate and glutathione as well as activities of glyoxalase I and II in liver and plasma were examined. After the start of the diet, hepatic contents of methylglyoxal and D-lactate increased to about 7 and 3 times that of the control, respectively. However, after 21 weeks the D-lactate content decreased from the elevated level, but remained at a higher level of 1.4 times the control. The hepatic glyoxalase I activity increased 1.2 to 1.7 times over the control during carcinogenesis, while glyoxalase II activity increased 160% during the precancerous state and decreased to 55% of control at 21 weeks. the hepatic level of reduced glutathione (GSH) increased and peaked after 4 weeks of the MDAB diet and decreased thereafter to 57% of the control level after 21 weeks. Both pyruvate and L-lactate levels increased in the liver and plasma of MDAB-fed rats when rats had obvious symptoms of hepatoma.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyruvaldehyde
/
Thiolester Hydrolases
/
Lactates
/
Lactoylglutathione Lyase
/
Liver Neoplasms
/
Methyldimethylaminoazobenzene
Limits:
Animals
Language:
En
Journal:
Res Exp Med (Berl)
Year:
1996
Document type:
Article
Affiliation country:
Japan