Enantiospecific synthesis and in vitro activity of selective inhibitors of rat brain kynureninase and kynurenine-3-hydroxylase.

Giordani, A; Corti, L; Cini, M; Bormetti, R; Marconi, M; Veneroni, O; Speciale, C; Varasi, M

Giordani, A; Corti, L; Cini, M; Bormetti, R; Marconi, M; Veneroni, O; Speciale, C; Varasi, M.

Affiliation

Giordani A; Pharmacia, R&D-CNS, Nerviano Milano, Italy.

Adv Exp Med Biol ; 398: 531-4, 1996.

Article in En | MEDLINE | ID: mdl-8906317

Subject(s)

Alanine/analogs & derivatives; Alanine/chemical synthesis; Benzoates/chemical synthesis; Brain/enzymology; Enzyme Inhibitors/chemical synthesis; Hydrolases/antagonists & inhibitors; Mixed Function Oxygenases/antagonists & inhibitors; Alanine/chemistry; Alanine/pharmacology; Animals; Benzoates/chemistry; Benzoates/pharmacology; Drug Design; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Indicators and Reagents; Kinetics; Kynurenine 3-Monooxygenase; Male; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Benzoates / Brain / Alanine / Enzyme Inhibitors / Hydrolases / Mixed Function Oxygenases Limits: Animals Language: En Journal: Adv Exp Med Biol Year: 1996 Document type: Article Affiliation country: Italy Country of publication: United States

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