Transglutaminase induction by various cell death and apoptosis pathways.
Experientia
; 52(10-11): 942-9, 1996 Oct 31.
Article
in En
| MEDLINE
| ID: mdl-8917724
ABSTRACT
Clarification of the molecular details of forms of natural cell death, including apoptosis, has become one of the most challenging issues of contemporary biomedical sciences. One of the effector elements of various cell death pathways is the covalent cross-linking of cellular proteins by transglutaminases. This review will discuss the accumulating data related to the induction and regulation of these enzymes, particularly of tissue type transglutaminase, in the molecular program of cell death. A wide range of signalling pathways can lead to the parallel induction of apoptosis and transglutaminase, providing a handle for better understanding the exact molecular interactions responsible for the mechanism of regulated cell death.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transglutaminases
/
Cell Death
/
Apoptosis
Limits:
Animals
Language:
En
Journal:
Experientia
Year:
1996
Document type:
Article
Affiliation country:
Hungary