Interaction of Rabphilin3 with synaptic vesicles through multiple regions.
Biochem Biophys Res Commun
; 228(2): 567-72, 1996 Nov 12.
Article
in En
| MEDLINE
| ID: mdl-8920952
ABSTRACT
Rabphilin3 is a downstream target protein of Rab3A small G protein, implicated in neurotransmitter release. We have previously reported that about 4 molecules of Rabphilin3 are associated with one synaptic vesicle through a vesicle anchoring protein(s). We have shown here that Rabphilin3 interacts with rat synaptic vesicles through at least three regions the N-terminal region (1-280 amino acids (aa)), the C-terminal region containing the two C2 domains (440-704 aa), and an unidentified region. A model for the interaction of Rabphilin3 with the vesicles is discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synaptic Vesicles
/
GTP-Binding Proteins
/
Rab GTP-Binding Proteins
/
Nerve Tissue Proteins
Limits:
Animals
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
1996
Document type:
Article
Affiliation country:
Japan
Country of publication:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA