[Treatment of neonatal hyperthyroidism with calcium iopodate]. / Traitement de l'hyperthyroïdie néonatale par l'iopodate de calcium.
Arch Pediatr
; 3(11): 1102-6, 1996 Nov.
Article
in Fr
| MEDLINE
| ID: mdl-8952775
ABSTRACT
BACKGROUND:
Treatment of hyperthyroidism in those neonates born to mothers with Grave's disease is difficult. Calcium ipodate, an agent for oral cholecystography, inhibits extra-thyroid conversion of T3 to T4 and diminishes thyroid secretion. CASE REPORTS Two neonates with clinical manifestations and biological findings of hyperthyroidism were given calcium ipodate orally, 400 mg every 3 days, from day 26 to 50 for the first patient and from day 9 to 18 for the second in association with a beta blocker. Clinical manifestations disappeared within 2 days and circulating levels of T3 and T4 were normalized within 2-5 days.CONCLUSIONS:
This treatment was effective and well-tolerated in both patients and in three others previously reported; it should be confirmed in a larger number of patients and controlled by measuring levels of antibodies directed against thyrotropin-releasing hormone receptors in order to avoid relapse after cessation of treatment as seen in our second patient.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triiodothyronine
/
Hyperthyroidism
/
Ipodate
Limits:
Female
/
Humans
/
Newborn
Language:
Fr
Journal:
Arch Pediatr
Year:
1996
Document type:
Article
Affiliation country:
France