The novel anticonvulsant SB 204269 binds to a stereospecific site in the mouse brain.
Eur J Pharmacol
; 314(3): R7-8, 1996 Oct 31.
Article
in En
| MEDLINE
| ID: mdl-8957267
ABSTRACT
The novel compound SB 204269 (trans-(+)-6-acetyl-4S-(4-fluorobenzoylamino)- 3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3R-ol, hemihydrate) shows potent anticonvulsant activity in the mouse maximal electroshock seizure threshold test. The binding of [3H]SB 204269 to mouse forebrain membranes is saturable (Bmax 217 fmol/mg protein, Kd 32 nM) and stereospecific. The excellent anticonvulsant profile of SB 204269, combined with the identification of a unique binding site for the compound, suggest that it has potential clinical utility as a novel treatment for epilepsy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzamides
/
Benzopyrans
/
Prosencephalon
/
Anticonvulsants
Limits:
Animals
Language:
En
Journal:
Eur J Pharmacol
Year:
1996
Document type:
Article
Affiliation country:
United kingdom