[Concise information on the structure and function of intraglomerular mesangia]. / Strucná informace o strukture a funkcích intraglomerulárního mesangia.

ABSTRACT

The area between glomerular capillaries is filled with special cellular structure-mesangium. Intraglomerular mesangium is composed from mononuclear stellar cells embedded into an amorphous extracellular matrix. It has several functions firm and compliant structural sustenance of capillaries, regulation of the ultrafiltration coefficient by means of the capillary surface area control, phagocytosis and removal of macromolecules and immune complexes, hormone secretion and production of bioactive substances (endothelin, prostaglandins, renin, cytokines, immunomodulatory peptides, components of the extracellular matrix etc.).