Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors.
Cytogenet Cell Genet
; 74(4): 286-90, 1996.
Article
in En
| MEDLINE
| ID: mdl-8976386
ABSTRACT
We report the cloning of a novel human gene, CMKLR1, which encodes a protein that has notable sequence and structural homology to the seven transmembrane G-protein linked chemokine receptors. This gene has 55% nucleotide sequence homology to the IL-8 type 1 receptor and 53% to the N-formyl peptide related receptor 1 genes. The mRNA of this receptors is expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow, and fetal liver. Using fluorescence in situ hybridization the gene encoding CMLKR1 (chemokine-like receptor 1) was localized to human chromosome 12q24.1.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosomes, Human, Pair 12
/
Cloning, Molecular
/
Receptors, Cytokine
/
Receptors, Chemokine
Limits:
Humans
Language:
En
Journal:
Cytogenet Cell Genet
Year:
1996
Document type:
Article
Affiliation country:
United States