Successful program to prevent aspergillus infections in children undergoing marrow transplantation: use of nasal amphotericin.
Bone Marrow Transplant
; 19(1): 43-7, 1997 Jan.
Article
in En
| MEDLINE
| ID: mdl-9012930
ABSTRACT
Aspergillus infections in the pediatric bone marrow transplant (BMT) patients are usually fatal. We began the use of a prophylactic nasal spray of amphotericin in 1990. This nasal spray was provided in addition to low-dose intravenous amphotericin. During the time of this study, the number of fatal cases of aspergillus in the pediatric BMT population was reduced significantly from 13.8% to 1.8% (P < 0.0025) thereby suggesting that the use of nasal amphotericin in this population helps to prevent fatal aspergillus infections. The lack of significant side-effects and the ease of administration make this a very helpful preventive measure in the supportive care of pediatric bone marrow transplant patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aspergillosis
/
Aspergillus
/
Amphotericin B
/
Bone Marrow Transplantation
/
Antifungal Agents
Limits:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
Language:
En
Journal:
Bone Marrow Transplant
Journal subject:
TRANSPLANTE
Year:
1997
Document type:
Article
Affiliation country:
United States