Simple extractive derivatization of methamphetamine and its metabolites in biological materials with Extrelut columns for their GC-MS determination.
J Anal Toxicol
; 21(1): 54-8, 1997.
Article
in En
| MEDLINE
| ID: mdl-9013294
A simple, extractive heptafluoro-n-butyrylation with Extrelut columns was devised to simultaneously measure methamphetamine (MAMP), amphetamine (AMP), 4-hydroxymethamphetamine (HMAMP), and 4-hydroxyamphetamine (HAMP) in biological materials by gas chromatography-mass spectrometry (GC-MS) using 4-methoxymethamphetamine-d5 as the internal standard. Human urine, human whole blood, and porcine skeletal muscle spiked with the stimulant standards were used for evaluating the method. After deproteinization and adjustment of the pH to 12.6, the sample was applied to an Extrelut column. Using the present method, AMP, MAMP, and HMAMP could be determined in an actual forensic case study.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
P-Hydroxyamphetamine
/
Amphetamine
/
Central Nervous System Stimulants
/
Gas Chromatography-Mass Spectrometry
/
Methamphetamine
Limits:
Animals
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Anal Toxicol
Year:
1997
Document type:
Article
Affiliation country:
Japan
Country of publication:
United kingdom