Intrathecally administered flumazenil and PK 11195 precipitate abstinence syndrome in freely moving diazepam dependent rats.

Wala, E P; Sloan, J W; Jing, X; Holtman, P H

Wala, E P; Sloan, J W; Jing, X; Holtman, P H.

Affiliation

Wala EP; University of Kentucky, Department of Anesthesiology, Lexington, USA.

Drug Alcohol Depend ; 43(3): 169-77, 1996 Dec 11.

Article in En | MEDLINE | ID: mdl-9023073

Subject(s)

Diazepam/metabolism; Flumazenil/administration & dosage; Flumazenil/pharmacology; Isoquinolines/pharmacology; Rats, Sprague-Dawley; Animals; Diazepam/blood; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography/drug effects; Female; Flumazenil/adverse effects; GABA-A Receptor Antagonists; Injections, Spinal; Rats; Tremor/chemically induced

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Collection: 01-internacional Database: MEDLINE Main subject: Flumazenil / Rats, Sprague-Dawley / Diazepam / Isoquinolines Limits: Animals Language: En Journal: Drug Alcohol Depend Year: 1996 Document type: Article Affiliation country: United States

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