Absence of p53 permits propagation of mutant cells following genotoxic damage.

Griffiths, S D; Clarke, A R; Healy, L E; Ross, G; Ford, A M; Hooper, M L; Wyllie, A H; Greaves, M

Griffiths, S D; Clarke, A R; Healy, L E; Ross, G; Ford, A M; Hooper, M L; Wyllie, A H; Greaves, M.

Affiliation

Griffiths SD; Leukaemia Research Fund Centre, Institute of Cancer Research, London, UK.

Oncogene ; 14(5): 523-31, 1997 Feb 06.

Article in En | MEDLINE | ID: mdl-9053850

Subject(s)

B-Lymphocytes/physiology; Genes, p53; Hematopoietic Stem Cells/physiology; T-Lymphocytes/physiology; Tumor Suppressor Protein p53/biosynthesis; Animals; Apoptosis/radiation effects; B-Lymphocytes/cytology; B-Lymphocytes/radiation effects; Cell Survival/radiation effects; Cells, Cultured; Colony-Forming Units Assay; Dose-Response Relationship, Radiation; Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/radiation effects; Heterozygote; Homozygote; Humans; Hypoxanthine Phosphoribosyltransferase/genetics; Interleukin-7/pharmacology; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Mutagenesis; Recombinant Proteins/pharmacology; T-Lymphocytes/drug effects; Tumor Suppressor Protein p53/deficiency; Tumor Suppressor Protein p53/genetics; X-Rays

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / B-Lymphocytes / T-Lymphocytes / Genes, p53 / Tumor Suppressor Protein p53 Limits: Animals / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 1997 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

Search on Google

Add to My VHL

XML

PubMed Links