Influence of anesthetics on the incidence of reperfusion-induced arrhythmias and sudden death in rats.
J Cardiovasc Pharmacol
; 29(2): 196-201, 1997 Feb.
Article
in En
| MEDLINE
| ID: mdl-9057068
ABSTRACT
PURPOSE:
We compared the influence of pentobarbital (P, 60 mg/kg), urethane (U, 1.8 g/kg), and a contribution of diazepam with ketamine hydrochloride (D+K, 10 + 100 mg/kg) anesthesia on the incidence of ischemia/ reperfusion-induced arrhythmias in rats. In anesthetized rats, myocardial ischemia was produced by a 6-min ligation of the left main coronary artery, followed by 5 min of reperfusion. The incidence of reperfusion-induced ventricular fibrillation (VF) and ventricular tachycardia (VT) was markedly decreased in the D+K-anesthetized animals compared with the P-anesthetized group (VF, 46 vs. 89%; VT, 64 vs. 94%). The mean blood pressure (MBP) before coronary ligation was significantly lower in U-anesthetized animals (72 +/- 3.5 vs. 102 +/- 4.1 and 108 +/- 5.9 mm Hg in P and D+K, respectively). The MBP recovery was the best in the D+K-anesthetized group. In experimental work, pentobarbitone anesthesia may be recommended for studying arrhythmias, while the combination of diazepam and ketamine may be useful for hemodynamic investigations.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arrhythmias, Cardiac
/
Myocardial Reperfusion Injury
/
Death, Sudden
/
Anesthetics
Type of study:
Incidence_studies
/
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
J Cardiovasc Pharmacol
Year:
1997
Document type:
Article
Affiliation country:
Hungary