Irreversible inhibition of high-affinity [3H]kainate binding by a novel photoactivatable analogue: (2'S,3'S,4'R)-2'-carboxy-4'-(2-diazo-1-oxo-3, 3,3-trifluoropropyl)-3'-pyrrolidinyl acetate.

Willis, C L; Wacker, D A; Bartlett, R D; Bleakman, D; Lodge, D; Chamberlin, A R; Bridges, R J

Willis, C L; Wacker, D A; Bartlett, R D; Bleakman, D; Lodge, D; Chamberlin, A R; Bridges, R J.

Affiliation

Willis CL; Department of Pharmaceutical Sciences, School of Pharmacy and Allied Health Sciences, University of Montana, Missoula 59812, USA.

J Neurochem ; 68(4): 1503-10, 1997 Apr.

Article in En | MEDLINE | ID: mdl-9084420

Subject(s)

Affinity Labels/chemical synthesis; Kainic Acid/pharmacology; Pyrrolidines/metabolism; Receptors, Kainic Acid/antagonists & inhibitors; Animals; Binding Sites/drug effects; Binding, Competitive/physiology; Cells, Cultured/chemistry; Cells, Cultured/physiology; Cerebral Cortex/cytology; Dose-Response Relationship, Drug; Humans; Kainic Acid/chemistry; Kainic Acid/metabolism; Kidney/cytology; Male; Neurons/chemistry; Neurons/cytology; Neurons/physiology; Patch-Clamp Techniques; Pyrrolidines/pharmacology; Radioligand Assay; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tritium; Ultraviolet Rays

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Affinity Labels / Receptors, Kainic Acid / Kainic Acid Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: J Neurochem Year: 1997 Document type: Article Affiliation country: United States

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