Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.

Nagiec, M M; Nagiec, E E; Baltisberger, J A; Wells, G B; Lester, R L; Dickson, R C

Nagiec, M M; Nagiec, E E; Baltisberger, J A; Wells, G B; Lester, R L; Dickson, R C.

Affiliation

Nagiec MM; Department of Biochemistry and the Lucille P. Markey Cancer Center, University of Kentucky Medical Center, Lexington, Kentucky 40536-0084, USA.

J Biol Chem ; 272(15): 9809-17, 1997 Apr 11.

Article in En | MEDLINE | ID: mdl-9092515

Subject(s)

Antifungal Agents/pharmacology; Depsipeptides; Drug Resistance, Microbial/genetics; Fungal Proteins/genetics; Hexosyltransferases/metabolism; Sphingolipids/biosynthesis; Amino Acid Sequence; Ceramides/metabolism; Fungal Proteins/chemistry; Fungal Proteins/metabolism; Molecular Sequence Data; Peptides, Cyclic/pharmacology; Saccharomyces cerevisiae; Sphingosine/analogs & derivatives; Sphingosine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Sphingolipids / Drug Resistance, Microbial / Fungal Proteins / Depsipeptides / Hexosyltransferases / Antifungal Agents Language: En Journal: J Biol Chem Year: 1997 Document type: Article Affiliation country: United States Country of publication: United States

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