Genotype of cytochrome P450 2E1 and alcohol-related blood pressure elevation in Japanese men.
Blood Press
; 6(2): 112-6, 1997 Mar.
Article
in En
| MEDLINE
| ID: mdl-9105651
ABSTRACT
Three-hundred-and-sixty-seven unrelated Japanese male workers aged between 36 and 61 years were analysed for the genotypes of cytochrome P450 2E1 (CYP2E1), and the association with alcohol-related health effects including blood pressure (BP) elevation. Homozygous for the c1 (wild) gene was found in 204 men (55%), homozygous for the c2 (variant) gene in 17 (5%), and heterozygous in 146 (40%). Arithmetic means of alcohol consumed per week in the genotypes of c1/c1, c1/c2 and c2/c2 were 218, 257 and 211 g, respectively, and were not statistically different. BP was elevated with the increase in alcohol consumption, and was significantly higher in the c2/c2 genotype than in the other genotypes among the subjects consuming 200 g or more of alcohol per week. Serum uric acid did not correlate with alcohol consumption in the whole subjects, but it was also higher in drinkers having the c2/c2 genotype. Although the number of subjects was too small for a definite conclusion to be drawn, these results suggest to some extent that Japanese men having the c2/c2 genotype of CYP2E1 are more sensitive to the pressor effect of alcohol. Further studies are required to confirm this.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Pressure
/
Alcohol Drinking
/
Cytochrome P-450 CYP2E1
/
Asian People
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Blood Press
Journal subject:
ANGIOLOGIA
Year:
1997
Document type:
Article
Affiliation country:
Japan