Pentoxifylline improves cell-mediated immunity and reduces human immunodeficiency virus (HIV) plasma viremia in asymptomatic HIV-seropositive persons.
J Infect Dis
; 175(5): 1210-5, 1997 May.
Article
in En
| MEDLINE
| ID: mdl-9129088
ABSTRACT
The effects of pentoxifylline on immunologic and virologic parameters were evaluated in 10 human immunodeficiency virus-infected patients not receiving antiretroviral treatment. Patients were asymptomatic, had 300-500 CD4 cells/microL, and received pentoxifylline (1200 mg/day orally) for 4 months. Peripheral blood mononuclear cells were tested before and at five time points during therapy. A transient increase in CD4 cells was observed in 8 of 9 patients, and CD8 cells increased in 7 of 9 patients. These increases were negatively correlated with susceptibility to in vitro mitogen-stimulated apoptotic cell death. Pentoxifylline had a temporary effect on mitogen-stimulated cytokine production; thus, interferon-gamma, interleukin (IL)-2, tumor necrosis factor-alpha, and lymphotoxin increased more than IL-10. Pentoxifylline also potentiated antigen-stimulated IL-2 production and proliferation in 8 of 9 patients and induced significant but transient decreases in plasma viremia in 7 of 9 patients. These preliminary findings suggest that pentoxifylline in vivo has an interesting but temporary influence on both immunologic and virologic parameters.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pentoxifylline
/
Lymphocytes
/
Adjuvants, Immunologic
/
Cytokines
/
HIV-1
/
HIV Seropositivity
/
CD4 Lymphocyte Count
/
Anti-HIV Agents
Limits:
Humans
Language:
En
Journal:
J Infect Dis
Year:
1997
Document type:
Article
Affiliation country:
Italy