Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo.

Komarova, E A; Chernov, M V; Franks, R; Wang, K; Armin, G; Zelnick, C R; Chin, D M; Bacus, S S; Stark, G R; Gudkov, A V

Komarova, E A; Chernov, M V; Franks, R; Wang, K; Armin, G; Zelnick, C R; Chin, D M; Bacus, S S; Stark, G R; Gudkov, A V.

Affiliation

Komarova EA; Department of Genetics, University of Illinois at Chicago, 60607, USA.

EMBO J ; 16(6): 1391-400, 1997 Mar 17.

Article in En | MEDLINE | ID: mdl-9135154

Subject(s)

Lac Operon; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism; 3T3 Cells; Animals; Apoptosis/genetics; Apoptosis/radiation effects; Base Sequence; DNA Damage; DNA Primers/genetics; Doxorubicin/pharmacology; Drug Resistance/genetics; Female; Gene Expression Regulation, Developmental/drug effects; Gene Expression Regulation, Developmental/radiation effects; Genes, Reporter; Genes, p53; Male; Mice; Mice, Knockout; Mice, Transgenic; Pregnancy; RNA, Messenger/genetics; RNA, Messenger/metabolism; Radiation Tolerance/genetics; Tissue Distribution; Transcriptional Activation/drug effects; Transcriptional Activation/radiation effects; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Lac Operon Type of study: Diagnostic_studies Limits: Animals / Pregnancy Language: En Journal: EMBO J Year: 1997 Document type: Article Affiliation country: United States

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