Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis.
J Exp Med
; 185(9): 1711-4, 1997 May 05.
Article
in En
| MEDLINE
| ID: mdl-9151908
ABSTRACT
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the central nervous system which serves as a model for the human disease multiple sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein-immunized mice. Thus, T lymphocytes transduced with retroviral vectors can deliver "regulatory cytokines" in a site-specific manner and may represent a viable therapeutic strategy for the treatment of autoimmune disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retroviridae
/
Interleukin-4
/
Encephalomyelitis, Autoimmune, Experimental
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Exp Med
Year:
1997
Document type:
Article
Affiliation country:
United States