Pyrrolopyrimidines: novel brain-penetrating antioxidants with neuroprotective activity in brain injury and ischemia models.

Hall, E D; Andrus, P K; Smith, S L; Fleck, T J; Scherch, H M; Lutzke, B S; Sawada, G A; Althaus, J S; Vonvoigtlander, P F; Padbury, G E; Larson, P G; Palmer, J R; Bundy, G L

Hall, E D; Andrus, P K; Smith, S L; Fleck, T J; Scherch, H M; Lutzke, B S; Sawada, G A; Althaus, J S; Vonvoigtlander, P F; Padbury, G E; Larson, P G; Palmer, J R; Bundy, G L.

Affiliation

Hall ED; CNS Diseases Research, Pharmacia & Upjohn, Inc., Kalamazoo, Michigan, USA.

J Pharmacol Exp Ther ; 281(2): 895-904, 1997 May.

Article in En | MEDLINE | ID: mdl-9152399

Subject(s)

Antioxidants/pharmacology; Brain Injuries/prevention & control; Brain Ischemia/prevention & control; Neuroprotective Agents/pharmacology; Pyrimidines/pharmacology; Animals; Antioxidants/pharmacokinetics; Biological Availability; Brain/drug effects; Brain/metabolism; Brain Injuries/metabolism; Brain Ischemia/metabolism; Female; Free Radical Scavengers; Gerbillinae; Lipid Peroxidation/drug effects; Male; Mice; Neuroprotective Agents/pharmacokinetics; Pyrimidines/pharmacokinetics; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Brain Injuries / Brain Ischemia / Neuroprotective Agents / Antioxidants Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 1997 Document type: Article Affiliation country: United States Country of publication: United States

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