The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT.

Jackson, T A; Richer, J K; Bain, D L; Takimoto, G S; Tung, L; Horwitz, K B

Jackson, T A; Richer, J K; Bain, D L; Takimoto, G S; Tung, L; Horwitz, K B.

Affiliation

Jackson TA; Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA.

Mol Endocrinol ; 11(6): 693-705, 1997 Jun.

Article in En | MEDLINE | ID: mdl-9171233

Subject(s)

DNA-Binding Proteins/physiology; Mifepristone/pharmacology; Nuclear Proteins/physiology; Receptors, Progesterone/agonists; Receptors, Progesterone/antagonists & inhibitors; Repressor Proteins/physiology; Ribosomal Proteins/physiology; Animals; Base Sequence; Binding Sites; COS Cells; DNA, Complementary; DNA-Binding Proteins/genetics; Gene Expression Regulation/drug effects; HeLa Cells; Humans; Leucine Zippers; Mice; Mifepristone/antagonists & inhibitors; Molecular Sequence Data; Nuclear Proteins/genetics; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Co-Repressor 2; Receptors, Progesterone/genetics; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/pharmacology; Repressor Proteins/genetics; Ribosomal Proteins/isolation & purification; Yeasts

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Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Ribosomal Proteins / Nuclear Proteins / Receptors, Progesterone / Mifepristone / DNA-Binding Proteins Limits: Animals / Humans Language: En Journal: Mol Endocrinol Journal subject: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Year: 1997 Document type: Article Affiliation country: United States Country of publication: United States

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