[Perinatal outcomes of newborn infants of mothers over 40 years old. A case-control study]. / Esiti perinatali di neonati da madre ultraquarantenne. Uno studio caso-controllo.
Minerva Ginecol
; 49(3): 81-4, 1997 Mar.
Article
in It
| MEDLINE
| ID: mdl-9173343
The changing life patterns for women in current society are accompanied by a postponement of pregnancy in advanced reproductive age. The aim of our study was to compare perinatal outcome among 314 newborns from women > or = 40 years old with 6.683 controls from mothers 20-29-year-old who delivered at our Division between 1983 and 1993. For each analyzed variable (birth weight, gestational age, congenital malformations, still-births, neonatal mortality and morbidity) the odds ratio (OR) and 95% confidence intervals (95% CI) were calculated for the group of women > or = 40 years old. The incidence of nulliparas in the older age group was 13.5%. The cesarean section rate was higher in the mature mothers than in their younger controls (52.1% vs 34.7%). The more frequent prenatal genetic management in women past the age of 35 years may be the reason for the reduced overall frequency of still-births and malformations in the group > or = 40 years. Preterm delivery was observed more frequently in the older mothers compared with controls (18.5% vs 11.7%). The frequency of LBW and VLBW was higher, but not significant, in the cases than in the controls. Newborns from older mothers had a significant increase of macrosomia (8% vs 4.8%) and a twice increase of mortality (3.2% vs 1.6%) and morbidity (20.4% vs 11.4%). These data suggest to improve the perinatal care of women > or = 40 years old.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Infant, Newborn
/
Pregnancy Outcome
/
Maternal Age
/
Pregnancy, High-Risk
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
/
Pregnancy
Language:
It
Journal:
Minerva Ginecol
Year:
1997
Document type:
Article
Country of publication:
Italy