Defective HIV-1 provirus encoding a multitarget-ribozyme inhibits accumulation of spliced and unspliced HIV-1 mRNAs, reduces infectivity of viral progeny, and protects the cells from pathogenesis.

Paik, S Y; Banerjea, A; Chen, C J; Ye, Z; Harmison, G G; Schubert, M

Paik, S Y; Banerjea, A; Chen, C J; Ye, Z; Harmison, G G; Schubert, M.

Affiliation

Paik SY; Molecular and Viral Genetics Section, LMMN, National Institute of Neurological Disorder and Stroke, NIH, Bethesda, MD 20892-4164, USA.

Hum Gene Ther ; 8(9): 1115-24, 1997 Jun 10.

Article in En | MEDLINE | ID: mdl-9189769

Subject(s)

HIV-1/genetics; HeLa Cells/virology; Proviruses/genetics; RNA Splicing; RNA, Catalytic/metabolism; CD4 Antigens/genetics; CD4 Antigens/metabolism; Cell Nucleus/genetics; Cell Nucleus/metabolism; Cell Nucleus/virology; Cytoplasm/genetics; Cytoplasm/metabolism; Cytoplasm/virology; DNA, Viral; Gene Products, env; Gene Products, tat; HIV-1/pathogenicity; HIV-2/genetics; Humans; Protein Biosynthesis; Proviruses/pathogenicity; RNA, Catalytic/genetics; RNA, Messenger/genetics; RNA, Viral; Transcription, Genetic; Transfection; Virus Replication; tat Gene Products, Human Immunodeficiency Virus

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Collection: 01-internacional Database: MEDLINE Main subject: HeLa Cells / RNA Splicing / RNA, Catalytic / HIV-1 / Proviruses Type of study: Etiology_studies Limits: Humans Language: En Journal: Hum Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 1997 Document type: Article Affiliation country: United States Country of publication: United States

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