Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression.
FASEB J
; 11(6): 443-8, 1997 May.
Article
in En
| MEDLINE
| ID: mdl-9194524
ABSTRACT
The tumor suppressor gene product p53 plays an important role in the cellular response to DNA damage. DNA damage can lead to p53-mediated growth arrest and apoptosis. High concentrations of nitric oxide (NO) and NO metabolites such as peroxynitrite and NO2 cause DNA damage and have been shown to be mutagenic. Furthermore, NO induces p53 accumulation and, as part of a feedback loop, p53 mediates transcriptional transrepression of inducible nitric oxide synthase. Recent studies have shown increased expression and activity of nitric oxide synthase isoforms in human cancer. NO has both genotoxic and angiogenic properties, so that increased NO production may select mutant p53 cells and contribute to human carcinogenesis and tumor progression.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genes, p53
/
Neoplasms
/
Nitric Oxide
Limits:
Animals
/
Humans
Language:
En
Journal:
FASEB J
Journal subject:
BIOLOGIA
/
FISIOLOGIA
Year:
1997
Document type:
Article
Affiliation country:
United States