Intracarotid recombinant human tumor necrosis factor-alpha reduces cerebral blood flow and methionine uptake in rat brain tumors.

Sasajima, T; Mineura, K; Kowada, M; Hatazawa, J; Miura, S

Sasajima, T; Mineura, K; Kowada, M; Hatazawa, J; Miura, S.

Affiliation

Sasajima T; Neurosurgical Service, Akita University Hospital, Japan.

J Neurooncol ; 34(2): 123-9, 1997 Sep.

Article in En | MEDLINE | ID: mdl-9210058

Subject(s)

Brain Neoplasms/drug therapy; Brain/blood supply; Cerebrovascular Circulation/drug effects; Glioma/drug therapy; Methionine/metabolism; Tumor Necrosis Factor-alpha/therapeutic use; Animals; Autoradiography; Biological Transport; Blood Pressure/drug effects; Brain Neoplasms/blood supply; Brain Neoplasms/metabolism; Brain Neoplasms/pathology; Carotid Artery, Internal; Glioma/blood supply; Glioma/metabolism; Glioma/pathology; Humans; Injections, Intra-Arterial; Male; Necrosis; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Recombinant Proteins/administration & dosage; Recombinant Proteins/therapeutic use; Regional Blood Flow/drug effects; Tritium; Tumor Necrosis Factor-alpha/administration & dosage

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Collection: 01-internacional Database: MEDLINE Main subject: Brain / Brain Neoplasms / Cerebrovascular Circulation / Tumor Necrosis Factor-alpha / Glioma / Methionine Limits: Animals / Humans / Male Language: En Journal: J Neurooncol Year: 1997 Document type: Article Affiliation country: Japan Country of publication: United States

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