Delivery of oligoribonucleotides to human hepatoma cells using cationic lipid particles conjugated to ferric protoporphyrin IX (heme).

Takle, G B; Thierry, A R; Flynn, S M; Peng, B; White, L; Devonish, W; Galbraith, R A; Goldberg, A R; George, S T

Takle, G B; Thierry, A R; Flynn, S M; Peng, B; White, L; Devonish, W; Galbraith, R A; Goldberg, A R; George, S T.

Affiliation

Takle GB; Innovir Laboratories, Inc., New York, NY 10021, USA.

Antisense Nucleic Acid Drug Dev ; 7(3): 177-85, 1997 Jun.

Article in En | MEDLINE | ID: mdl-9212908

Subject(s)

Carcinoma, Hepatocellular/pathology; Fatty Acids, Monounsaturated/administration & dosage; Heme/administration & dosage; Liver Neoplasms/pathology; Neoplasm Proteins/metabolism; Oligoribonucleotides/administration & dosage; Phosphatidylethanolamines/administration & dosage; Quaternary Ammonium Compounds/administration & dosage; Receptors, Cell Surface/metabolism; Animals; Cations; Cell Line; Cell Nucleus/metabolism; Chlorocebus aethiops; Cytoplasm/metabolism; DNA, Recombinant/administration & dosage; DNA, Recombinant/pharmacokinetics; Drug Carriers; Fatty Acids, Monounsaturated/chemistry; Fatty Acids, Monounsaturated/pharmacokinetics; Genes, Reporter; Genetic Vectors/administration & dosage; Genetic Vectors/pharmacokinetics; Heme/chemistry; Heme/pharmacokinetics; Humans; Kidney; Luciferases/biosynthesis; Luciferases/genetics; Mice; Microscopy, Fluorescence; Oligoribonucleotides/chemistry; Oligoribonucleotides/pharmacokinetics; Organ Specificity; Particle Size; Phosphatidylethanolamines/chemistry; Phosphatidylethanolamines/pharmacokinetics; Quaternary Ammonium Compounds/chemistry; Quaternary Ammonium Compounds/pharmacokinetics; Recombinant Fusion Proteins/biosynthesis; Recombinant Fusion Proteins/genetics; Species Specificity; Tumor Cells, Cultured; Vero Cells

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Oligoribonucleotides / Phosphatidylethanolamines / Fatty Acids, Monounsaturated / Carcinoma, Hepatocellular / Receptors, Cell Surface / Heme / Quaternary Ammonium Compounds / Liver Neoplasms / Neoplasm Proteins Language: En Journal: Antisense Nucleic Acid Drug Dev Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / FARMACOLOGIA Year: 1997 Document type: Article Affiliation country: United States

Search on Google

Add to My VHL

XML

PubMed Links