Potent, long-acting, orally-active bradykinin antagonists for a wide range of applications.
Immunopharmacology
; 36(2-3): 167-72, 1997 Jun.
Article
in En
| MEDLINE
| ID: mdl-9228542
ABSTRACT
Actions of bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; BK) are mediated by constitutively expressed B2 receptors, that require the full BK peptide chain, and by B1 receptors, induced in inflammation, that use BK(1-8) as ligand. In addition to many physiological and pathophysiological functions, the growth factor activity of BK evidently allows it to act as an autocrine stimulant for small cell lung cancer. A new group of BK antagonists containing the novel amino acid a-(2-indanyl)glycine provides extremely potent broad-spectrum as well as selective antagonists for all these functions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bradykinin
/
Bradykinin Receptor Antagonists
Limits:
Humans
Language:
En
Journal:
Immunopharmacology
Year:
1997
Document type:
Article
Affiliation country:
United States