Effect of the haloperidol tetrahydropyridine metabolite 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6- tetrahydropyridine on dopamine receptor and transporter binding. A nonhuman primate 123I-iodobenzamide and 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane single photon emission computed tomographic study.

Oliver, D W; Dormehl, I C; Van der Schyf, C J; Neumeyer, J L; Hugo, N; Keeve, R; Rossouw, N T; Müller-Gärtner, H W; Castagnoli, N

Oliver, D W; Dormehl, I C; Van der Schyf, C J; Neumeyer, J L; Hugo, N; Keeve, R; Rossouw, N T; Müller-Gärtner, H W; Castagnoli, N.

Affiliation

Oliver DW; Department of Pharmacology, Potchefstroom University for Christian Higher Education, Potchefstroom, South Africa.

Arzneimittelforschung ; 47(6): 692-9, 1997 Jun.

Article in En | MEDLINE | ID: mdl-9239444

Subject(s)

Antipsychotic Agents/pharmacology; Carrier Proteins/drug effects; Dopamine/metabolism; Haloperidol/analogs & derivatives; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Receptors, Dopamine/drug effects; Animals; Antipsychotic Agents/administration & dosage; Benzamides; Brain/diagnostic imaging; Brain/drug effects; Brain/metabolism; Cocaine/analogs & derivatives; Dopamine Plasma Membrane Transport Proteins; Haloperidol/administration & dosage; Haloperidol/pharmacology; Iodine Radioisotopes; Male; Papio; Pyrrolidines; Tomography, Emission-Computed, Single-Photon

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Antipsychotic Agents / Membrane Glycoproteins / Carrier Proteins / Dopamine / Receptors, Dopamine / Haloperidol / Nerve Tissue Proteins Type of study: Guideline Limits: Animals Language: En Journal: Arzneimittelforschung Year: 1997 Document type: Article Affiliation country: South Africa

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