In vitro receptor imaging for characterization of human solid tumors.
Nucl Med Biol
; 21(5): 771-4, 1994 Jul.
Article
in En
| MEDLINE
| ID: mdl-9241653
ABSTRACT
Since many of the factors involved in tumor growth and progression act through a receptor-mediated mechanism, we applied in vitro receptor imaging techniques to study the intratumoral distribution and concentration of receptor-molecules having experimental biological relevance in such processes. Here we summarize the results of a study concerning the role of urokinase receptor (uPAR) in the acquisition of an invasive phenotype by tumor cells. Independently of the system studied, we demonstrated that in vitro receptor imaging techniques can be used to define the biological characteristics of human solid tumors and can contribute to clarify the complex network of ligand/receptor interactions leading to tumor spread.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Diseases
/
Breast Neoplasms
/
Receptors, Cell Surface
Limits:
Humans
Language:
En
Journal:
Nucl Med Biol
Journal subject:
BIOLOGIA
/
MEDICINA NUCLEAR
Year:
1994
Document type:
Article
Affiliation country:
Italy